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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization - Nature Structural & Molecular Biology

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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization - Nature Structural & Molecular Biology

Subnuclear compartmentalization has been proposed to play an important role in gene regulation by segregating active and inactive parts of the genome in distinct physical and biochemical environments. During X chromosome inactivation (XCI), the noncoding Xist RNA coats the X chromosome, triggers gene silencing and forms a dense body of heterochromatin from which the transcription machinery appears to be excluded.

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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization - Nature Structural & Molecular Biology

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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization - Nature Structural & Molecular Biology

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