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Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2 - Nature Structural & Molecular Biology

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Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2 - Nature Structural & Molecular Biology

A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition. In mammals, organic cation transporter (OCT) subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively) are polyspecific transporters responsible for the uptake and clearance of structurally diverse cationic compounds in the liver and kidneys, respectively.

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Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2 - Nature Structural & Molecular Biology

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Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2 - Nature Structural & Molecular Biology

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