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Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice - Nature Cardiovascular Research

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Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice - Nature Cardiovascular Research

Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression1. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase receptor (ALK1)) is a recently identified receptor that mediates LDL entry and transcytosis in endothelial cells (ECs)2,3. However, the role of this pathway in vivo is not yet known.

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Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice - Nature Cardiovascular Research

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Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice - Nature Cardiovascular Research

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