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Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner - Nature Aging

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Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner - Nature Aging

Aging markedly increases cancer risk, yet our mechanistic understanding of how aging influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an inhibitor of Wnt signaling that is frequently mutated in adrenocortical carcinoma, leads to the induction of cellular senescence that remodels the tissue microenvironment and ultimately permits metastatic adrenal cancer in old animals.

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Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner - Nature Aging

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Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner - Nature Aging

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