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In situ tumour arrays reveal early environmental control of cancer immunity - Nature

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In situ tumour arrays reveal early environmental control of cancer immunity - Nature

The immune phenotype of a tumour is a key predictor of its response to immunotherapy1–4. Patients who respond to checkpoint blockade generally present with immune-inflamed5–7 tumours that are highly infiltrated by T cells. However, not all inflamed tumours respond to therapy, and even lower response rates occur among tumours that lack T cells (immune desert) or that spatially exclude T cells to the periphery of the tumour lesion (immune excluded)8.

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In situ tumour arrays reveal early environmental control of cancer immunity - Nature

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