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Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex - Nature Structural & Molecular Biology

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Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex - Nature Structural & Molecular Biology

Throughout bacteria, archaea and eukarya, certain tRNA transcripts contain introns. Pre-tRNAs with introns require splicing to form the mature anticodon stem loop. In eukaryotes, tRNA splicing is initiated by the heterotetrameric tRNA splicing endonuclease (TSEN) complex. All TSEN subunits are essential, and mutations within the complex are associated with a family of neurodevelopmental disorders known as pontocerebellar hypoplasia (PCH).

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Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex - Nature Structural & Molecular Biology

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Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex - Nature Structural & Molecular Biology

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