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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels - Nature Chemical Biology

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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels - Nature Chemical Biology

A major pharmacological assumption is that lowering disease-promoting protein levels is generally beneficial. For example, inhibiting metastasis activator BACH1 is proposed to decrease cancer metastases. Testing such assumptions requires approaches to measure disease phenotypes while precisely adjusting disease-promoting protein levels. Here we developed a two-step strategy to integrate protein-level tuning, noise-aware synthetic gene circuits into a well-defined human genomic safe harbor locus.

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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels - Nature Chemical Biology

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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels - Nature Chemical Biology

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