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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover - Nature Cell Biology

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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover - Nature Cell Biology

This study reveals that thermogenic stimuli activate mitochondrial proteolysis via LONP1 to sustain the succinate levels required for efficient conversion of white adipocytes to beige adipocytes. Our work highlights mitochondrial proteases (mitoproteases) as a link between environmental stimuli, metabolite levels and cell identity switching.

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environment ecology nature earth adipocytes conversion cell white beige cell biology biology microbiology

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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover - Nature Cell Biology

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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover - Nature Cell Biology

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