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Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells - Nature Communications

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Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells - Nature Communications

Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrient-deprived media and a conditional knockout female mouse model to study the mechanism underlying PD-1 upregulation. Reduced methionine increases PD-1 expression on CD4 T cells.

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environment ecology nature earth methionine cancer cells cells upregulation expression cd4 cell biology biology microbiology

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Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells - Nature Communications

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Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells - Nature Communications

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