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Regulatory T cells play a crucial part in radio-immunotherapy resistance of brain tumors - Nature Cancer

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Regulatory T cells play a crucial part in radio-immunotherapy resistance of brain tumors - Nature Cancer

Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy. We examined the dynamic changes of immune cells that occur in the tumor microenvironment of radio-immunotherapy-treated glioblastomas and identified a subpopulation of regulatory T cells with increased immunosuppressive activity. Depletion of this cell population improved survival in a mouse model of glioblastoma.

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Regulatory T cells play a crucial part in radio-immunotherapy resistance of brain tumors - Nature Cancer

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Regulatory T cells play a crucial part in radio-immunotherapy resistance of brain tumors - Nature Cancer

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