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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging - Nature Aging

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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging - Nature Aging

Chronic systemic inflammation is one of the hallmarks of the aging immune system. Here we show that activated T cells from older adults contribute to inflammaging by releasing mitochondrial DNA (mtDNA) into their environment due to an increased expression of the cytokine-inducible SH2-containing protein (CISH). CISH targets ATP6V1A, an essential component of the proton pump V-ATPase, for proteasomal degradation, thereby impairing lysosomal function.

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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging - Nature Aging

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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging - Nature Aging

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