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Ageing-associated changes in transcriptional elongation influence longevity - Nature

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Ageing-associated changes in transcriptional elongation influence longevity - Nature

Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing1–4. However, the molecular mechanisms leading to the loss of transcriptional fidelity are so far elusive, as are ways of preventing it. Here we profiled and analysed genome-wide, ageing-related changes in transcriptional processes across different organisms: nematodes, fruitflies, mice, rats and humans.

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Ageing-associated changes in transcriptional elongation influence longevity - Nature

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Ageing-associated changes in transcriptional elongation influence longevity - Nature

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