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Establishment and function of chromatin organization at replication origins - Nature

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Establishment and function of chromatin organization at replication origins - Nature

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome replication as it loads the replicative helicase—the minichromosome maintenance (MCM) complex—at replication origins1. Replication origins display a stereotypic nucleosome organization with nucleosome depletion at ORC-binding sites and flanking arrays of regularly spaced nucleosomes2–4.

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Establishment and function of chromatin organization at replication origins - Nature

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Establishment and function of chromatin organization at replication origins - Nature

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