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Structural basis for GSDMB pore formation and its targeting by IpaH7.8 - Nature

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Structural basis for GSDMB pore formation and its targeting by IpaH7.8 - Nature

Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence through pyroptosis1,2. Among GSDMs, GSDMB is unique owing to its distinct lipid-binding profile and a lack of consensus on its pyroptotic potential3–7. Recently, GSDMB was shown to exhibit direct bactericidal activity through its pore-forming activity4.

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Structural basis for GSDMB pore formation and its targeting by IpaH7.8 - Nature

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Structural basis for GSDMB pore formation and its targeting by IpaH7.8 - Nature

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