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Exploiting liver metabolism for tissue-specific cancer targeting - Nature Cancer

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Exploiting liver metabolism for tissue-specific cancer targeting - Nature Cancer

Although targeting cancer cells on the basis of tissue-specific expression of key factors is an important strategy in precision oncology, few such therapies exist. Chemical screening now identifies YC-1 as a tissue-specific anti-cancer compound that is activated in the liver by the sulfotransferase enzyme SULT1A1.

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Exploiting liver metabolism for tissue-specific cancer targeting - Nature Cancer

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