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Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy - Nature Materials

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Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy - Nature Materials

Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies, motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature-sensing peptides disrupt membrane-enveloped virus particles in the exosome size range, we devised a broadly useful strategy that repurposes an engineered antiviral peptide to disrupt membrane-enveloped T-EXOs for synergistic cancer immunotherapy.

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Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy - Nature Materials

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Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy - Nature Materials

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