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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse - Nature Cancer

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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse - Nature Cancer

Patients with estrogen receptor (ER)-positive breast cancer are at risk of metastatic relapse for decades after primary tumor resection and treatment, a consequence of dormant disseminated tumor cells (DTCs) reawakening at secondary sites. Here we use syngeneic ER+ mouse models in which DTCs display a dormant phenotype in young mice but accelerated metastatic outgrowth in an aged or fibrotic microenvironment.

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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse - Nature Cancer

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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse - Nature Cancer

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