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Enantioselective synthesis of tetraarylmethanes through meta-hydroxyl-directed benzylic substitution - Nature Synthesis
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Benzylic carbocations bearing an ortho- or para-hydroxyl group can be stabilized by forming quinone methides, which have been explored in enantioselective synthesis. However, those with a meta-hydroxyl group have remained almost unexplored in organic synthesis. The lack of resonance stabilization by a typical quinone methide form renders them not only difficult to generate, but also challenging to control for asymmetric bond formation.
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