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Actin up: shifting chromosomes toward repair, but also translocations - Nature Structural & Molecular Biology

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Actin up: shifting chromosomes toward repair, but also translocations - Nature Structural & Molecular Biology

Nuclear actin polymerization helps facilitate chromosome compartment switches that can shift damaged DNA toward a nuclear environment that is favorable for DNA repair. Yet shifting multiple broken DNA strands together can also increase the likelihood of misjoining of the DNA ends and subsequent formation of translocations.

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Actin up: shifting chromosomes toward repair, but also translocations - Nature Structural & Molecular Biology

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Actin up: shifting chromosomes toward repair, but also translocations - Nature Structural & Molecular Biology

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