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Bicarbonate transport as a vulnerability in pancreatic cancer - Nature Cancer

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Bicarbonate transport as a vulnerability in pancreatic cancer - Nature Cancer

Pancreatic ductal cells transport bicarbonate from blood to pancreatic juice. A study shows that pancreatic cancer retains SLC4A4-mediated bicarbonate import to fuel cancer growth via enhanced glycolysis and establish a pro-tumorigenic immune microenvironment. Targeting SLC4A4 mitigates acidosis and can be combined with checkpoint blockade.

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Bicarbonate transport as a vulnerability in pancreatic cancer - Nature Cancer

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Bicarbonate transport as a vulnerability in pancreatic cancer - Nature Cancer

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