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Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage - Nature Communications

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Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage - Nature Communications

Acetaminophen overdose is one of the leading causes of acute liver failure and liver transplantation in the Western world. Magnesium is essential in several cellular processess. The Cyclin M family is involved in magnesium transport across cell membranes. Herein, we identify that among all magnesium transporters, only Cyclin M4 expression is upregulated in the liver of patients with acetaminophen overdose, with disturbances in magnesium serum levels.

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Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage - Nature Communications

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Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage - Nature Communications

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