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Structure of the human heparan sulfate polymerase complex EXT1-EXT2 - Nature Communications

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Structure of the human heparan sulfate polymerase complex EXT1-EXT2 - Nature Communications

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by the bi-functional glycosyltransferases EXT1 and EXT2, which generate the glycan backbone consisting of repeating N-acetylglucosamine and glucuronic acid units. The molecular mechanism of heparan sulfate chain polymerization remains, however, unknown.

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Structure of the human heparan sulfate polymerase complex EXT1-EXT2 - Nature Communications

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Structure of the human heparan sulfate polymerase complex EXT1-EXT2 - Nature Communications

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