Article
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing - Nature Structural & Molecular Biology
Rating:
0.0
Views:
55
Likes:
1
Library:
1
It is estimated that 10%–30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene product and are potential therapeutic targets. However, systematic diagnosis or prediction of splicing variants is yet to be established, especially for the near-exon intronic splice region. The major challenge lies in the redundant and ill-defined branch sites and other splicing motifs therein.
Rate This Post
Rate The Educational Value
Rate The Ease of Understanding and Presentation
Interesting or Boring? Rate the Entertainment Value