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Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine - Nature Chemistry

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Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine - Nature Chemistry

The combination of next-generation DNA sequencing technologies and bioinformatics has revitalized natural product discovery. Using a bioinformatic search strategy, we recently identified ∼600 gene clusters in otherwise overlooked streptococci that code for ribosomal peptide natural products synthesized by radical S-adenosylmethionine enzymes. These grouped into 16 subfamilies and pointed to an unexplored microbiome biosynthetic landscape.

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Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine - Nature Chemistry

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Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine - Nature Chemistry

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