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Clathrin-associated AP-1 controls termination of STING signalling - Nature

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Clathrin-associated AP-1 controls termination of STING signalling - Nature

Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to activate immunity during infection, cancer and immunotherapy1–10. Precise regulation of STING is essential to ensure balanced immune responses and prevent detrimental autoinflammation11–16.

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Clathrin-associated AP-1 controls termination of STING signalling - Nature

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Clathrin-associated AP-1 controls termination of STING signalling - Nature

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