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Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway - Cell Death & Differentiation

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Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway - Cell Death & Differentiation

The role of autophagy in cancer is context-dependent. In the present study, we aimed to investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin (SIRT) family member, SIRT4, was significantly associated autophagy pathway in pancreatic ductal adenocarcinoma (PDAC). Specifically, in vitro cell culture experiments and in vivo transgenic and xenografted animal models revealed that SIRT4 could inhibit tumor growth and promote autophagy in PDAC.

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Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway - Cell Death & Differentiation

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Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway - Cell Death & Differentiation

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