@curator

1 year ago

Article

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma - Nature Metabolism

Rating: 0.0

Likes: 1

Library: 1

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma - Nature Metabolism

Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner. The large extracellular vesicle HK1 is hijacked by hepatocellular carcinoma (HCC) cells, leading to accelerated glycolysis and HCC progression.

Rate This Post

Rate The Educational Value

Rate The Ease of Understanding and Presentation

Interesting or Boring? Rate the Entertainment Value

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma - Nature Metabolism

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge
for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge
for Humanity's Progress

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma - Nature Metabolism

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress