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Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion - Nature Microbiology

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Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion - Nature Microbiology

Defence-associated sirtuins (DSRs) comprise a family of proteins that defend bacteria from phage infection via an unknown mechanism. These proteins are common in bacteria and harbour an N-terminal sirtuin (SIR2) domain. In this study we report that DSR proteins degrade nicotinamide adenine dinucleotide (NAD+) during infection, depleting the cell of this essential molecule and aborting phage propagation.

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Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion - Nature Microbiology

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Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion - Nature Microbiology

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