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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency - Nature

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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency - Nature

Diabetes mellitus is prevalent among women of reproductive age, and many women are left undiagnosed or untreated1. Gestational diabetes has profound and enduring effects on the long-term health of the offspring2,3. However, the link between pregestational diabetes and disease risk into adulthood in the next generation has not been sufficiently investigated. Here we show that pregestational hyperglycaemia renders the offspring more vulnerable to glucose intolerance.

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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency - Nature

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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency - Nature

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