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An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control - npj Systems Biology and Applications

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An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control - npj Systems Biology and Applications

Growth and environmental responses are essential for living organisms to survive and adapt to constantly changing environments. In order to simulate new conditions and capture dynamic responses to environmental shifts in a developing whole-cell model of E. coli, we incorporated additional regulation, including dynamics of the global regulator guanosine tetraphosphate (ppGpp), along with dynamics of amino acid biosynthesis and translation.

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An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control - npj Systems Biology and Applications

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An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control - npj Systems Biology and Applications

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