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Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria - Cell Death & Differentiation

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Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria - Cell Death & Differentiation

Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including inflammation, cell proliferation or cell death. This is a developmentally essential function because in utero deletion of endothelial Caspase-8 causes systemic circulatory collapse during embryogenesis. Whether endothelial Caspase-8 is also required for cardiovascular patency during adulthood was unknown.

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Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria - Cell Death & Differentiation

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Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria - Cell Death & Differentiation

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