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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies - Nature Microbiology

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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies - Nature Microbiology

Human parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe disease in older people and infants. Currently, vaccines against hPIV3 are in clinical trials but none have been approved yet. The haemagglutinin-neuraminidase (HN) and fusion (F) surface glycoproteins of hPIV3 are major antigenic determinants. Here we describe naturally occurring potently neutralizing human antibodies directed against both surface glycoproteins of hPIV3.

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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies - Nature Microbiology

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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies - Nature Microbiology

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