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ATG16L1 induces the formation of phagophore-like membrane cups - Nature Structural & Molecular Biology

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ATG16L1 induces the formation of phagophore-like membrane cups - Nature Structural & Molecular Biology

The hallmark of non-selective autophagy is the formation of cup-shaped phagophores that capture bulk cytoplasm. The process is accompanied by the conjugation of LC3B to phagophores by an E3 ligase complex comprising ATG12–ATG5 and ATG16L1. Here we combined two complementary reconstitution approaches to reveal the function of LC3B and its ligase complex during phagophore expansion.

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ATG16L1 induces the formation of phagophore-like membrane cups - Nature Structural & Molecular Biology

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ATG16L1 induces the formation of phagophore-like membrane cups - Nature Structural & Molecular Biology

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