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Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference - Nature Communications

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Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference - Nature Communications

TadA-derived cytosine base editors (TadCBEs) enable programmable C•G-to-T•A editing while retaining the small size, high on-target activity, and low off-target activity of TadA deaminases. Existing TadCBEs, however, exhibit residual A•T-to-G•C editing at certain positions and lower editing efficiencies at some sequence contexts and with non-SpCas9 targeting domains.

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technology cyber security computer security selectivity sequence cytosine base editor

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Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference - Nature Communications

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Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference - Nature Communications

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