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21 days ago

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Constructing co-stimulation to boost TCR therapy - Nature Cancer

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Constructing co-stimulation to boost TCR therapy - Nature Cancer

T cell receptor (TCR)-engineered T cells offer great promise for targeting tumor antigens in cancer therapy. A synthetic fusion protein termed 80BB, which can simultaneously activate the CD28 and 4-1BB co-stimulatory pathways, is now shown to enhance overall functionality of therapeutic TCR/CD3-dependent T cells in an antigen-agnostic manner.

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Constructing co-stimulation to boost TCR therapy - Nature Cancer

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Constructing co-stimulation to boost TCR therapy - Nature Cancer

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