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Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells - Nature Nanotechnology

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Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells - Nature Nanotechnology

Cellular programming of naïve T cells can improve the efficacy of adoptive T-cell therapy. However, the current ex vivo engineering of T cells requires the pre-activation of T cells, which causes them to lose their naïve state. In this study, cationic-polymer-functionalized nanowires were used to pre-program the fate of primary naïve CD8+ T cells to achieve a therapeutic response in vivo.

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Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells - Nature Nanotechnology

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Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells - Nature Nanotechnology

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