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Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice - Acta Pharmacologica Sinica

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Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice - Acta Pharmacologica Sinica

Paclitaxel (PTX) serves as a primary chemotherapy agent against diverse solid tumors including breast cancer, lung cancer, head and neck cancer and ovarian cancer, having severe adverse effects including PTX-induced peripheral neuropathy (PIPN) and hypersensitivity reactions (HSR). A recommended anti-allergic agent diphenhydramine (DIP) has been used to alleviate PTX-induced HSR.

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Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice - Acta Pharmacologica Sinica

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Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice - Acta Pharmacologica Sinica

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