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Weak neuronal glycolysis sustains cognition and organismal fitness - Nature Metabolism

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Weak neuronal glycolysis sustains cognition and organismal fitness - Nature Metabolism

The energy cost of neuronal activity is mainly sustained by glucose1,2. However, in an apparent paradox, neurons modestly metabolize glucose through glycolysis3–6, a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase–fructose-2,6-bisphosphatase-3 (PFKFB3)3,7,8, a key glycolysis-promoting enzyme.

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Weak neuronal glycolysis sustains cognition and organismal fitness - Nature Metabolism

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