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Repurposing a plant peptide cyclase for targeted lysine acylation - Nature Chemistry

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Repurposing a plant peptide cyclase for targeted lysine acylation - Nature Chemistry

Transpeptidases are powerful tools for protein engineering but are largely restricted to acting at protein backbone termini. Alternative enzymatic approaches for internal protein labelling require bulky recognition motifs or non-proteinogenic reaction partners, potentially restricting which proteins can be modified or the types of modification that can be installed.

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Repurposing a plant peptide cyclase for targeted lysine acylation - Nature Chemistry

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Repurposing a plant peptide cyclase for targeted lysine acylation - Nature Chemistry

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