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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution - Nature Structural & Molecular Biology

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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution - Nature Structural & Molecular Biology

Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a TRPM2 chanzyme from choanoflagellates that integrates two seemingly incompatible functions into a single peptide: a channel module activated by ADP-ribose with high

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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution - Nature Structural & Molecular Biology

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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution - Nature Structural & Molecular Biology

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