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ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish - Communications Biology

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ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish - Communications Biology

Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormalities, culminating in bone marrow failure. A major gap exists in our knowledge of the regulatory functions of ADA2 during inflammation and hematopoiesis, mainly due to the absence of an ADA2 orthologue in rodents.

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ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish - Communications Biology

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ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish - Communications Biology

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