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Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse - Cell Death & Disease

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Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse - Cell Death & Disease

Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. It is a severe cancer predisposition syndrome with a poor prognosis, partly due to the frequent development of subsequent primary tumors following DNA-damaging therapies. Here we explored, for the first time, the effectiveness of mutant p53 rescue compound in treating LFS-mimicking mice harboring a deleterious p53 mutation.

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Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse - Cell Death & Disease

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Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse - Cell Death & Disease

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