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Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications - Nature Genetics

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Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications - Nature Genetics

Chromatin modifications are linked with regulating patterns of gene expression, but their causal role and context-dependent impact on transcription remains unresolved. Here we develop a modular epigenome editing platform that programs nine key chromatin modifications, or combinations thereof, to precise loci in living cells.

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Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications - Nature Genetics

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Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications - Nature Genetics

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