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Paternal microbiome perturbations impact offspring fitness - Nature
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The gut microbiota operates at the interface of host–environment interactions to influence human homoeostasis and metabolic networks1–4. Environmental factors that unbalance gut microbial ecosystems can therefore shape physiological and disease-associated responses across somatic tissues5–9. However, the systemic impact of the gut microbiome on the germline—and consequently on the F1 offspring it gives rise to—is unexplored10.
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