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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature Structural & Molecular Biology

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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature Structural & Molecular Biology

The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability, epigenetics and immunity. Yet, it remains unknown whether DNA ADP-ribosylation (DNA-ADPr) promotes genome stability and how it is regulated. Here, we show that telomeres are subject to DNA-ADPr catalyzed by PARP1 and removed by TARG1.

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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature Structural & Molecular Biology

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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature Structural & Molecular Biology

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