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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway - Nature Microbiology

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway - Nature Microbiology

The cyclic-oligonucleotide-based anti-phage signalling system (CBASS) is a type of innate prokaryotic immune system. Composed of a cyclic GMP–AMP synthase (cGAS) and CBASS-associated proteins, CBASS uses cyclic oligonucleotides to activate antiviral immunity. One major class of CBASS contains a homologue of eukaryotic ubiquitin-conjugating enzymes, which is either an E1–E2 fusion or a single E2. However, the functions of single E2s in CBASS remain elusive.

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway - Nature Microbiology

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway - Nature Microbiology

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