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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 - Nature Chemical Biology

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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 - Nature Chemical Biology

Prokaryotes are equipped with a variety of resistance strategies to survive frequent viral attacks or invading mobile genetic elements. Among these, CRISPR–Cas surveillance systems are abundant and have been studied extensively. This Review focuses on CRISPR–Cas type VI Cas13 systems that use single-subunit RNA-guided Cas endonucleases for targeting and subsequent degradation of foreign RNA, thereby providing adaptive immunity.

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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 - Nature Chemical Biology

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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 - Nature Chemical Biology

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