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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis - Nature Biotechnology

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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis - Nature Biotechnology

Efforts to advance RNA aptamers as a new therapeutic modality have been limited by their susceptibility to degradation and immunogenicity. In a previous study, we demonstrated synthesized short double-stranded region-containing circular RNAs (ds-cRNAs) with minimal immunogenicity targeted to dsRNA-activated protein kinase R (PKR). Here we test the therapeutic potential of ds-cRNAs in a mouse model of imiquimod-induced psoriasis. We

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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis - Nature Biotechnology

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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis - Nature Biotechnology

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