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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 - Nature Aging

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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 - Nature Aging

Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically characterize human ovarian aging. Spatiotemporal molecular signatures of the eight types of ovarian cells during aging are observed. An analysis of age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway in oocyte aging.

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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 - Nature Aging

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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 - Nature Aging

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