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17 days ago

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Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology

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Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology

Reversible protein phosphorylation is a central signaling mechanism in eukaryotes. Although mass-spectrometry-based phosphoproteomics has become routine, identification of non-canonical phosphorylation has remained a challenge. Here we report a tailored workflow to detect and reliably assign protein pyrophosphorylation in two human cell lines, providing, to our knowledge, the first direct evidence of endogenous protein pyrophosphorylation.

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Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology

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Extensive protein pyrophosphorylation revealed in human cell lines - Nature Chemical Biology

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